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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAPKAPK5
All Species:
12.73
Human Site:
Y375
Identified Species:
23.33
UniProt:
Q8IW41
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IW41
NP_003659.2
473
54220
Y375
T
K
P
K
D
S
V
Y
I
H
D
H
E
N
G
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001102910
666
74053
Y570
T
K
P
K
D
S
V
Y
I
H
D
H
E
N
G
Dog
Lupus familis
XP_534678
804
89494
Y706
T
K
P
K
D
C
V
Y
I
H
D
R
E
N
G
Cat
Felis silvestris
Mouse
Mus musculus
O54992
473
54134
Y375
T
K
P
K
D
G
I
Y
I
H
D
H
E
N
G
Rat
Rattus norvegicus
Q66H84
384
43204
M310
H
P
W
I
N
Q
S
M
E
V
P
Q
T
P
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521063
278
31941
P210
V
I
A
Q
C
I
L
P
Q
A
G
E
N
E
D
Chicken
Gallus gallus
Q5F3L1
789
89022
Q501
G
E
L
L
E
R
I
Q
K
K
Q
H
F
S
E
Frog
Xenopus laevis
NP_001085020
377
43533
M309
H
P
W
I
T
Q
S
M
Q
I
P
P
T
P
L
Zebra Danio
Brachydanio rerio
NP_001002336
471
53898
F375
T
K
P
N
D
E
L
F
I
N
D
P
E
N
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P49071
359
41383
P291
Y
N
A
V
P
Q
T
P
L
C
T
G
R
M
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_500006
366
41523
E298
S
N
L
N
D
Q
R
E
Q
W
T
D
M
Q
D
Sea Urchin
Strong. purpuratus
XP_001194739
473
54175
I376
G
Q
S
I
D
N
K
I
G
E
E
Q
P
P
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9ZV15
583
64702
I476
A
D
L
K
D
S
E
I
L
G
L
M
Q
A
A
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
70.7
58
N.A.
97.2
34.4
N.A.
57.2
21.1
34
87
N.A.
32.3
N.A.
34.6
56
Protein Similarity:
100
N.A.
70.7
58.3
N.A.
98.7
52.8
N.A.
58.1
35.3
52
94.2
N.A.
49.2
N.A.
52.4
72.3
P-Site Identity:
100
N.A.
100
86.6
N.A.
86.6
0
N.A.
0
6.6
0
53.3
N.A.
0
N.A.
6.6
6.6
P-Site Similarity:
100
N.A.
100
86.6
N.A.
93.3
6.6
N.A.
13.3
33.3
0
73.3
N.A.
6.6
N.A.
13.3
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.1
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
37.3
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
16
0
0
0
0
0
0
8
0
0
0
8
8
% A
% Cys:
0
0
0
0
8
8
0
0
0
8
0
0
0
0
0
% C
% Asp:
0
8
0
0
62
0
0
0
0
0
39
8
0
0
16
% D
% Glu:
0
8
0
0
8
8
8
8
8
8
8
8
39
8
16
% E
% Phe:
0
0
0
0
0
0
0
8
0
0
0
0
8
0
0
% F
% Gly:
16
0
0
0
0
8
0
0
8
8
8
8
0
0
31
% G
% His:
16
0
0
0
0
0
0
0
0
31
0
31
0
0
0
% H
% Ile:
0
8
0
24
0
8
16
16
39
8
0
0
0
0
0
% I
% Lys:
0
39
0
39
0
0
8
0
8
8
0
0
0
0
8
% K
% Leu:
0
0
24
8
0
0
16
0
16
0
8
0
0
0
24
% L
% Met:
0
0
0
0
0
0
0
16
0
0
0
8
8
8
0
% M
% Asn:
0
16
0
16
8
8
0
0
0
8
0
0
8
39
0
% N
% Pro:
0
16
39
0
8
0
0
16
0
0
16
16
8
24
0
% P
% Gln:
0
8
0
8
0
31
0
8
24
0
8
16
8
8
0
% Q
% Arg:
0
0
0
0
0
8
8
0
0
0
0
8
8
0
0
% R
% Ser:
8
0
8
0
0
24
16
0
0
0
0
0
0
8
0
% S
% Thr:
39
0
0
0
8
0
8
0
0
0
16
0
16
0
0
% T
% Val:
8
0
0
8
0
0
24
0
0
8
0
0
0
0
0
% V
% Trp:
0
0
16
0
0
0
0
0
0
8
0
0
0
0
0
% W
% Tyr:
8
0
0
0
0
0
0
31
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _